Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Identifieur interne : 001C54 ( Main/Exploration ); précédent : 001C53; suivant : 001C55Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Auteurs : RBID : pubmed:19738430Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular (metabolism), Carcinoma, Hepatocellular (pathology), Carcinoma, Hepatocellular (radionuclide imaging), France, Humans, Immunohistochemistry, Indium Radioisotopes (diagnostic use), Indium Radioisotopes (pharmacokinetics), Liver Neoplasms (metabolism), Liver Neoplasms (pathology), Liver Neoplasms (radionuclide imaging), Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Radionuclide Imaging (methods), Radiopharmaceuticals (diagnostic use), Radiopharmaceuticals (pharmacokinetics), Receptors, Somatostatin (analysis), Receptors, Somatostatin (metabolism), Somatostatin (analogs & derivatives), Somatostatin (diagnostic use), Somatostatin (pharmacokinetics), Treatment Outcome.
- MESH :
- chemical , analogs & derivatives : Somatostatin.
- chemical , analysis : Receptors, Somatostatin.
- chemical , diagnostic use : Indium Radioisotopes, Radiopharmaceuticals, Somatostatin.
- chemical , metabolism : Receptors, Somatostatin.
- chemical , pharmacokinetics : Indium Radioisotopes, Radiopharmaceuticals, Somatostatin.
- geographic : France.
- metabolism : Carcinoma, Hepatocellular, Liver Neoplasms.
- methods : Radionuclide Imaging.
- pathology : Carcinoma, Hepatocellular, Liver Neoplasms.
- radionuclide imaging : Carcinoma, Hepatocellular, Liver Neoplasms.
- Adult, Aged, Aged, 80 and over, Humans, Immunohistochemistry, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Treatment Outcome.
Abstract
Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment.
PubMed: 19738430
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.</title><author><name sortKey="Nguyen Khac, Eric" uniqKey="Nguyen Khac E">Eric Nguyen-Khac</name><affiliation wicri:level="1"><nlm:affiliation>Service d'Hépato-Gastroentérologie CHU Amiens, Amiens, France. nguyen-khac.eric@chu-amiens.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service d'Hépato-Gastroentérologie CHU Amiens, Amiens</wicri:regionArea><placeName><region type="région">Picardie</region><settlement type="city">Amiens</settlement></placeName></affiliation></author><author><name sortKey="Ollivier, Isabelle" uniqKey="Ollivier I">Isabelle Ollivier</name></author><author><name sortKey="Aparicio, Thomas" uniqKey="Aparicio T">Thomas Aparicio</name></author><author><name sortKey="Moullart, Veronique" uniqKey="Moullart V">Véronique Moullart</name></author><author><name sortKey="Hugentobler, Alexis" uniqKey="Hugentobler A">Alexis Hugentobler</name></author><author><name sortKey="Lebtahi, Rachida" uniqKey="Lebtahi R">Rachida Lebtahi</name></author><author><name sortKey="Lobry, Celine" uniqKey="Lobry C">Céline Lobry</name></author><author><name sortKey="Susini, Christiane" uniqKey="Susini C">Christiane Susini</name></author><author><name sortKey="Duhamel, Christian" uniqKey="Duhamel C">Christian Duhamel</name></author><author><name sortKey="Hommel, Severine" uniqKey="Hommel S">Séverine Hommel</name></author><author><name sortKey="Cadranel, Jean Francois" uniqKey="Cadranel J">Jean François Cadranel</name></author><author><name sortKey="Joly, Jean Paul" uniqKey="Joly J">Jean-paul Joly</name></author><author><name sortKey="Barbare, Jean Claude" uniqKey="Barbare J">Jean Claude Barbare</name></author><author><name sortKey="Tramier, Blaise" uniqKey="Tramier B">Blaise Tramier</name></author><author><name sortKey="Dupas, Jean Louis" uniqKey="Dupas J">Jean Louis Dupas</name></author></titleStmt><publicationStmt><date when="2009">2009</date><idno type="RBID">pubmed:19738430</idno><idno type="pmid">19738430</idno><idno type="wicri:Area/Main/Corpus">001D03</idno><idno type="wicri:Area/Main/Curation">001D03</idno><idno type="wicri:Area/Main/Exploration">001C54</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Carcinoma, Hepatocellular (metabolism)</term><term>Carcinoma, Hepatocellular (pathology)</term><term>Carcinoma, Hepatocellular (radionuclide imaging)</term><term>France</term><term>Humans</term><term>Immunohistochemistry</term><term>Indium Radioisotopes (diagnostic use)</term><term>Indium Radioisotopes (pharmacokinetics)</term><term>Liver Neoplasms (metabolism)</term><term>Liver Neoplasms (pathology)</term><term>Liver Neoplasms (radionuclide imaging)</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Staging</term><term>Radionuclide Imaging (methods)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Receptors, Somatostatin (analysis)</term><term>Receptors, Somatostatin (metabolism)</term><term>Somatostatin (analogs & derivatives)</term><term>Somatostatin (diagnostic use)</term><term>Somatostatin (pharmacokinetics)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Radiopharmaceuticals</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Somatostatin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Indium Radioisotopes</term><term>Radiopharmaceuticals</term><term>Somatostatin</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radionuclide Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Neoplasm Staging</term><term>Treatment Outcome</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19738430</PMID><DateCreated><Year>2009</Year><Month>12</Month><Day>28</Day></DateCreated><DateCompleted><Year>2010</Year><Month>06</Month><Day>25</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1555-8576</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>21</Issue><PubDate><Year>2009</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Cancer biology & therapy</Title><ISOAbbreviation>Cancer Biol. Ther.</ISOAbbreviation></Journal><ArticleTitle>Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.</ArticleTitle><Pagination><MedlinePgn>2033-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment.</AbstractText><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To evaluate SSTR screening with SRS in aHC patients.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nguyen-Khac</LastName><ForeName>Eric</ForeName><Initials>E</Initials><Affiliation>Service d'Hépato-Gastroentérologie CHU Amiens, Amiens, France. nguyen-khac.eric@chu-amiens.fr</Affiliation></Author><Author ValidYN="Y"><LastName>Ollivier</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Aparicio</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Moullart</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Hugentobler</LastName><ForeName>Alexis</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lebtahi</LastName><ForeName>Rachida</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lobry</LastName><ForeName>Céline</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Susini</LastName><ForeName>Christiane</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Duhamel</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hommel</LastName><ForeName>Séverine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Cadranel</LastName><ForeName>Jean François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Joly</LastName><ForeName>Jean-paul</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Barbare</LastName><ForeName>Jean Claude</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Tramier</LastName><ForeName>Blaise</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Dupas</LastName><ForeName>Jean Louis</ForeName><Initials>JL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>11</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Biol Ther</MedlineTA><NlmUniqueID>101137842</NlmUniqueID><ISSNLinking>1538-4047</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Receptors, Somatostatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>138661-02-6</RegistryNumber><NameOfSubstance>pentetreotide</NameOfSubstance></Chemical><Chemical><RegistryNumber>51110-01-1</RegistryNumber><NameOfSubstance>Somatostatin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Cancer Biol Ther. 2009 Nov;8(21):2040-1</RefSource><PMID Version="1">19823044</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Carcinoma, Hepatocellular</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radionuclide Imaging</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Receptors, Somatostatin</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Somatostatin</DescriptorName><QualifierName MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2009</Year><Month>11</Month><Day>5</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>6</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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